Eosinophilic bioactivities in severe asthma
نویسندگان
چکیده
منابع مشابه
Eosinophilic bioactivities in severe asthma
Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth factors. Eosinophils may persist in the blood and...
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Affiliations: Dept of Pulmonary Medicine, Mainz University Hospital, Mainz, Germany. Dept of Respiratory Medicine, Université Paris-Sud, Paris, France. Dept of Respiratory Medicine and Allergology, Skåne University Hospital, Lund, Sweden. Dept of Respiratory Medicine, Aix-Marseille University, Marseille, France. Dept of Respiratory Medicine, Queen’s University Belfast, Belfast, UK. Nuffield Dep...
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Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal outcome, in a small percentage of patients. Within the different inflammatory cascades involved in asthma, eosinophils play a central role in the pathogenesis and largely influence disease severity. In...
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BACKGROUND Some patients with severe asthma have frequent exacerbations associated with persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled glucocorticoids with or without oral glucocorticoids. METHODS In this randomized, double-blind, double-dummy study, we assigned 576 patients with recurrent asthma exacerbations and evidence of eosinophilic inflammation...
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ژورنال
عنوان ژورنال: World Allergy Organization Journal
سال: 2016
ISSN: 1939-4551
DOI: 10.1186/s40413-016-0112-5