Eosinophilic bioactivities in severe asthma

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Eosinophilic bioactivities in severe asthma

Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth factors. Eosinophils may persist in the blood and...

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Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal outcome, in a small percentage of patients. Within the different inflammatory cascades involved in asthma, eosinophils play a central role in the pathogenesis and largely influence disease severity. In...

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ژورنال

عنوان ژورنال: World Allergy Organization Journal

سال: 2016

ISSN: 1939-4551

DOI: 10.1186/s40413-016-0112-5